Home PipelineEnoblituzumab (anti-B7-H3)

Background

Enoblituzumab is an investigational monoclonal antibody that targets B7-H3 and has been enhanced using MacroGenics’ Fc Optimization platform. B7-H3 is a protein in the B7 family of immune regulator proteins. B7-H3 is widely expressed by a number of different tumor types and may play a key role in regulating the immune response to various types of cancer.

Clinical Development

Enoblituzumab was evaluated in a Phase 1 clinical study in combination with an anti-PD-1 monoclonal antibody in patients with B7-H3-expressing melanoma, squamous cell carcinoma of the head and neck (SCCHN), non-small cell lung cancer (NSCLC) and urothelial cancer. Data were presented at the Society for Immunotherapy of Cancer (SITC) Annual Meeting in November 2018.

To further inform the development of this molecule, MacroGenics plans to evaluate the activity of both enoblituzumab plus retifanlimab (an anti-PD-1 monoclonal antibody) in PD-L1 positive patients and enoblituzumab plus tebotelimab (a PD-1 × LAG-3 bispecific DART® molecule) in PD-L1 negative patients as chemotherapy‐free regimens in front‐line recurrent and metastatic SCCHN.

Our Rights

MacroGenics is collaborating on the development and commercialization of enoblituzumab with I-Mab Biopharma in Greater China. MacroGenics retains full development and commercialization rights in all other territories.

Clinical Trials

Presentations & Publications

Relevant Publications and Presentations can be found at https://www.macrogenics.com/publications/.

The safety and efficacy of investigational agents and/or investigational uses of approved products have not been established.

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