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Overview

MacroGenics has a diverse portfolio of oncology product candidates with several clinical trials currently underway or planned for the near future. Set forth below is the company’s development pipeline of product candidates for which we have retained commercialization or other important rights in the U.S. or more broadly (as of May 2025).

Program (Target) Potential Indication(s) Modality Preclinical Phase 1 Phase 2 Phase 3 Partner / Sponsor
Lorigerlimab (PD-1 × CTLA-4) mCRPC (+docetaxel) LORIKEET Study DART®
 

PROC/CCGC
LINNET Study
DART
 

MGC026 (B7-H3) Multiple Solid Tumors ADC
 

MGC028 (ADAM9) Multiple Solid Tumors ADC
 

MGC030 (Undisclosed) Multiple Solid Tumors ADC
 

Oncology
Lorigerlimab (PD-1 × CTLA-4)
mCRPC (+docetaxel) LORIKEET Study
Modality: DART®
Preclinical Phase 1 Phase 2 Phase 3
 

PROC/CCGC LINNET Study
Modality: DART
Preclinical Phase 1 Phase 2 Phase 3
 

MGC026 (B7-H3)
Multiple Solid Tumors
Modality: ADC
Preclinical Phase 1 Phase 2 Phase 3
 

MGC028 (ADAM9)
Multiple Solid Tumors
Modality: ADC
Preclinical Phase 1 Phase 2 Phase 3
 

 
MGC030 (Undisclosed)
Multiple Solid Tumors
ADC
Preclinical Phase 1 Phase 2 Phase 3
 

Partnered Programs

In addition to the molecules identified above, MacroGenics has out-licensed various product candidates for which it retains certain economic rights. These molecules provide potential sources of future cash flow and platform validation and are identified below.

Program (Target) Potential Indication(s) Modality Preclinical Phase 1 Phase 2 Phase 3 Marketed Partner
MARGENZA® (HER2)  HER2+ Metastatic Breast Cancer Fc-optimized mAb
 

Tersera logo
ZYNYZ® (PD-1)  Merkel Cell Carcinoma mAb
 

Incyte logo
Squamous Cell Anal Carcinoma mAb
sBLA approval anticipated 2H2025 (per Incyte)

NSCLC mAb

TZIELD® (CD3) Stage 2 “At Risk” T1D mAb
Multiple regulatory decisions expected 2H2025 (per Sanofi)

Sanofi logo
Stage 3 “Early Onset” T1D mAb
 

MGD024 (CD123 × CD3)  CD123+ Heme Malignancies DART
 

Exclusive OptionGilead logo
Bispecific (Undisclosed) Multiple Solid Tumors DART/TRIDENT®
 

Gilead logo

MARGENZA® (HER2) 
HER2+ Metastatic Breast Cancer
Modality: Fc-optimized mAb
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Partner / Sponsor

Eversana logo

ZYNYZ (PD-1) 
Merkel Cell Carcinoma
Modality: mAb
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Partner / Sponsor

Incyte logo

Squamous Cell Anal Carcinoma
Modality: mAb
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 
sBLA approval anticipated 2H2025 (per Incyte)
Partner / Sponsor

Incyte logo

NSCLC
Modality: mAb
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Partner / Sponsor

Incyte logo

TZIELD® (CD3)
Stage 2 “At Risk” T1D
Modality: mAb
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Multiple regulatory decisions expected 2H2025 (per Sanofi)
Stage 3 “Early Onset” T1D
Modality: mAb
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Partner / Sponsor

Sanofi logo

MGD024 (CD123 × CD3) 
CD123+ Heme Malignancies
Modality: DART
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Partner / Sponsor

Exclusive OptionGilead logo

Bispecific (Undisclosed)
Multiple Solid Tumors
Modality: DART/TRIDENT®
Preclinical Phase 1 Phase 2 Phase 3 Marketed
 

Partner / Sponsor

Gilead logo

MGD = DART MGC = ADC
The safety and efficacy of investigational agents and/or investigational uses of approved products have not been established. Pipeline reflects current status of each program or most recently completed phase of development.

MARGENZA global rights were sold to TerSera Therapeutics LLC, pursuant to which TerSera paid MacroGenics $40M at closing; MacroGenics may receive additional sales milestone payments of up to aggregate of $35M. MacroGenics paid $8M amendment fee to its current commercialization partner in 4Q2024. MacroGenics will manufacture MARGENZA drug substance on behalf of TerSera going forward.

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