Overview
MacroGenics has a diverse portfolio of oncology product candidates with several clinical trials currently underway or planned for the near future. Set forth below is the company’s development pipeline of product candidates for which we have retained commercialization or other important rights in the U.S. or more broadly (as of May 2025).
Program (Target) |
Potential Indication(s) |
Modality |
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Partner / Sponsor |
Lorigerlimab (PD-1 × CTLA-4) |
mCRPC (+docetaxel) LORIKEET Study |
DART® |
|
|
PROC/CCGC LINNET Study |
DART |
|
|
|
MGC026 (B7-H3) |
Multiple Solid Tumors |
ADC |
|
|
|
MGC028 (ADAM9) |
Multiple Solid Tumors |
ADC |
|
|
|
MGC030 (Undisclosed) |
Multiple Solid Tumors |
ADC |
|
|
|
Oncology
mCRPC (+docetaxel) LORIKEET Study
Modality: DART®
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
|
PROC/CCGC LINNET Study
Modality: DART
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
|
Multiple Solid Tumors
Modality: ADC
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
|
Multiple Solid Tumors
Modality: ADC
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
|
Multiple Solid Tumors
ADC
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
|
Partnered Programs
In addition to the molecules identified above, MacroGenics has out-licensed various product candidates for which it retains certain economic rights. These molecules provide potential sources of future cash flow and platform validation and are identified below.
HER2+ Metastatic Breast Cancer
Modality: Fc-optimized mAb
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
|
Merkel Cell Carcinoma
Modality: mAb
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
|
Squamous Cell Anal Carcinoma
Modality: mAb
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
sBLA approval anticipated 2H2025 (per Incyte)
|
NSCLC
Modality: mAb
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
|
Stage 2 “At Risk” T1D
Modality: mAb
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
Multiple regulatory decisions expected 2H2025 (per Sanofi)
|
Stage 3 “Early Onset” T1D
Modality: mAb
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
|
CD123+ Heme Malignancies
Modality: DART
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
|
Partner / Sponsor
Exclusive Option
Multiple Solid Tumors
Modality: DART/TRIDENT®
Preclinical |
Phase 1 |
Phase 2 |
Phase 3 |
Marketed |
|
MGD = DART MGC = ADC
The safety and efficacy of investigational agents and/or investigational uses of approved products have not been established. Pipeline reflects current status of each program or most recently completed phase of development.
MARGENZA global rights were sold to TerSera Therapeutics LLC, pursuant to which TerSera paid MacroGenics $40M at closing; MacroGenics may receive additional sales milestone payments of up to aggregate of $35M. MacroGenics paid $8M amendment fee to its current commercialization partner in 4Q2024. MacroGenics will manufacture MARGENZA drug substance on behalf of TerSera going forward.