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Lorigerlimab (PD-1 × CTLA-4) – MacroGenics
Home PipelineLorigerlimab (PD-1 × CTLA-4)


Lorigerlimab (previously known as MGD019) is an investigational, bispecific DART® molecule that was designed to enhance CTLA-4 blockade on dual-expressing, tumor-infiltrating lymphocytes compared to a PD-1/CTLA-4 monoclonal antibody (mAb) combination therapy, while maintaining maximal PD-1 blockade on all PD-1-expressing cells.

Clinical Development

Based upon the establishment of a recommended Phase 2 dose from a dose escalation study, lorigerlimab is being evaluated in a dose expansion study in microsatellite-stable colorectal cancer, non-small cell lung cancer, metastatic castration-resistant prostate cancer and melanoma.

MacroGenics is also evaluating the activity of MGC018 (an investigational B7-H3-directed antibody-drug conjugate) plus lorigerlimab in a Phase 1 study of patients with advanced solid tumors.

Our Rights

MacroGenics retains global rights to lorigerlimab.

Clinical Trials

Presentations & Publications

Relevant Publications and Presentations can be found at

The safety and efficacy of investigational agents and/or investigational uses of approved products have not been established.

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MacroGenics is not responsible for any content on the third party website.

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