Home Pipeline

Overview

MacroGenics has a diverse portfolio of oncology product candidates with several clinical trials currently underway or planned for the near future. Set forth below is the company’s development pipeline of product candidates for which we have retained commercialization or other important rights in the U.S. or more broadly (as of December 2022).

In addition to the molecules identified below, MacroGenics has out-licensed various other clinical-stage product candidates for which it retains certain economic rights. These include retifanlimab and teplizumab.

Program (Target) Potential Indication(s) First-in-Human (Phase 1) Proof-of-Concept
(Phase 2)
Pivotal
(Phase 3)
Major Market Rights
Vobramitamab Duocarmazine (MGC018)
(B7-H3)
mCRPC (TAMARACK study)
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Multiple Solid Tumors
(+lorigerlimab)
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Lorigerlimab
(PD-1 × CTLA-4)
mCRPC, Melanoma, MSS CRC, NSCLC
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Tebotelimab
(PD-1 × LAG-3)
Solid Tumors & Heme Malignancies
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Greater China
MGD024
(CD123 × CD3)
CD123+ Heme Malignancies
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Option Agreement
IMGC936
(ADAM9)
Multiple Solid Tumors
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50/50

Oncology
mCRPC (TAMARACK study)
Phase 1 Phase 2 Phase3
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Multiple Solid Tumors (+lorigerlimab)
Phase 1 Phase 2 Phase3
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Major Market Rights:

Lorigerlimab
(PD-1 × CTLA-4)
mCRPC, Melanoma, MSS CRC, NSCLC
Phase 1 Phase 2 Phase3
placeholder

Major Market Rights:

Tebotelimab
(PD-1 × LAG-3)
Solid Tumors & Heme Malignancies
Phase 1 Phase 2 Phase3
placeholder

Major Market Rights:

Greater China
MGD024
(CD123 × CD3)
CD123+ Heme Malignancies
Phase 1 Phase 2 Phase3
placeholder

Major Market Rights:

Option Agreement
IMGC936
(ADAM9)
Multiple Solid Tumors
Phase 1 Phase 2 Phase3
placeholder

Major Market Rights:

50/50
MGD = DART MGC = ADC

The safety and efficacy of investigational agents and/or investigational uses of approved products have not been established. Pipeline reflects current status of each program or most recently completed phase of development.

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