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Overview
MacroGenics has a diverse portfolio of oncology product candidates with several clinical trials currently underway or planned for the near future. Set forth below is the company’s development pipeline of product candidates for which we have retained commercialization or other important rights in the U.S. or more broadly (as of December 2025).
| Program (Target) | Potential Indication(s) | Modality | Preclinical | Phase 1 | Phase 2 | Phase 3 | Partner / Sponsor | ||
|---|---|---|---|---|---|---|---|---|---|
| Lorigerlimab (PD-1 × CTLA-4) | PROC/CCGC LINNET Study |
DART® |
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| MGC026 (B7-H3) | Multiple Solid Tumors | ADC |
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| MGC028 (ADAM9) | Multiple Solid Tumors | ADC |
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| MGC030 (Undisclosed) | Multiple Solid Tumors | ADC |
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Oncology
Lorigerlimab (PD-1 × CTLA-4)
PROC/CCGC LINNET Study
Modality: DART
| Preclinical | Phase 1 | Phase 2 | Phase 3 |
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MGC026 (B7-H3)
Multiple Solid Tumors
Modality: ADC
| Preclinical | Phase 1 | Phase 2 | Phase 3 |
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MGC028 (ADAM9)
Multiple Solid Tumors
Modality: ADC
| Preclinical | Phase 1 | Phase 2 | Phase 3 |
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MGC030 (Undisclosed)
Multiple Solid Tumors
ADC
| Preclinical | Phase 1 | Phase 2 | Phase 3 |
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Partnered Programs
In addition to the molecules identified above, MacroGenics has out-licensed various product candidates for which it retains certain economic rights. These molecules provide potential sources of future cash flow and platform validation and are identified below.
| Program (Target) | Potential Indication(s) | Modality | Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed | Partner | ||
|---|---|---|---|---|---|---|---|---|---|---|
| MARGENZA® (HER2) | HER2+ Metastatic Breast Cancer | Fc-optimized mAb |
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| ZYNYZ® (PD-1) | Merkel Cell Carcinoma | mAb |
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| Squamous Cell Anal Carcinoma | mAb |
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| NSCLC | mAb |
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| TZIELD® (CD3) | Stage 2 “At Risk” T1D | mAb |
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| Stage 3 “Early Onset” T1D | mAb |
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| MGD024 (CD123 × CD3) | CD123+ Heme Malignancies | DART |
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Exclusive Option |
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| Bispecific (Undisclosed) | Multiple Solid Tumors | TRIDENT® |
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| Bispecific (Undisclosed) | Undisclosed | DART |
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MARGENZA® (HER2)
HER2+ Metastatic Breast Cancer
Modality: Fc-optimized mAb
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
ZYNYZ™ (PD-1)
Merkel Cell Carcinoma
Modality: mAb
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
Squamous Cell Anal Carcinoma
Modality: mAb
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
NSCLC
Modality: mAb
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
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Partner / Sponsor
TZIELD® (CD3)
Stage 2 “At Risk” T1D
Modality: mAb
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Stage 3 “Early Onset” T1D
Modality: mAb
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
MGD024 (CD123 × CD3)
CD123+ Heme Malignancies
Modality: DART
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
Exclusive Option
Bispecific (Undisclosed)
Multiple Solid Tumors
Modality: DART/TRIDENT®
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
Bispecific (Undisclosed)
Undisclosed
T-Cell Engager
| Preclinical | Phase 1 | Phase 2 | Phase 3 | Marketed |
|---|---|---|---|---|
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Partner / Sponsor
MGD = DART MGC = ADC